GDP-fucose protein O-fucosyltransferase 2 (POFUT2)
Homo sapiens — UniProt Q9Y2G5
Data last refreshed: (UniProt release unknown)
Key facts
GDP-fucose protein O-fucosyltransferase 2 (POFUT2) is a protein from Homo sapiens identified by UniProt accession Q9Y2G5, 429 residues long. MolForge cross-references it against 0 known binders and 46 disease associations.
- UniProt accession: Q9Y2G5; gene symbol POFUT2.
- Organism: Homo sapiens.
- Length: 429 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, smoking behaviour measurement and head and neck squamous cell carcinoma.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | GDP-fucose protein O-fucosyltransferase 2 |
|---|---|
| UniProt accession | Q9Y2G5 |
| Gene | POFUT2 |
| Organism | Homo sapiens |
| Length | 429 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (46)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.48
- smoking behaviour measurement · score 0.20
- head and neck squamous cell carcinoma · score 0.16
- gastric adenocarcinoma · score 0.14
- esophageal cancer · score 0.12
- BMI-adjusted waist-hip ratio · score 0.08
- body fat percentage · score 0.07
- Torticollis · score 0.07
- body mass index · score 0.06
- cortical surface area measurement · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9Y2G5-F1 | alphafold | PREDICTED | 90.45 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9Y2G5.
Amino-acid sequence (429 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with POFUT2?
The strongest Open Targets associations for POFUT2 are neurodegenerative disease, smoking behaviour measurement, head and neck squamous cell carcinoma, gastric adenocarcinoma and esophageal cancer.
How long is the POFUT2 protein?
The Homo sapiens POFUT2 protein (UniProt Q9Y2G5) is 429 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9Y2G5 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9Y2G5 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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