Pleckstrin homology domain-containing family A member 6 (PLEKHA6)
Homo sapiens — UniProt Q9Y2H5
Data last refreshed: (UniProt release unknown)
Key facts
Pleckstrin homology domain-containing family A member 6 (PLEKHA6) is a protein from Homo sapiens identified by UniProt accession Q9Y2H5, 1048 residues long. MolForge cross-references it against 0 known binders and 43 disease associations.
- UniProt accession: Q9Y2H5; gene symbol PLEKHA6.
- Organism: Homo sapiens.
- Length: 1048 amino acids.
- Top disease associations (Open Targets): lymphocyte count, platelet count and monocyte count.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Pleckstrin homology domain-containing family A member 6 |
|---|---|
| UniProt accession | Q9Y2H5 |
| Gene | PLEKHA6 |
| Organism | Homo sapiens |
| Length | 1048 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (43)
Diseases linked to this target (Open Targets).
- lymphocyte count · score 0.36
- platelet count · score 0.36
- monocyte count · score 0.35
- electrocardiography · score 0.32
- platelet crit · score 0.32
- erythrocyte count · score 0.27
- hemoglobin measurement · score 0.26
- glioblastoma multiforme · score 0.26
- body height · score 0.25
- breast adenocarcinoma · score 0.25
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9Y2H5-F1 | alphafold | PREDICTED | 56.44 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9Y2H5.
Amino-acid sequence (1048 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with PLEKHA6?
The strongest Open Targets associations for PLEKHA6 are lymphocyte count, platelet count, monocyte count, electrocardiography and platelet crit.
How long is the PLEKHA6 protein?
The Homo sapiens PLEKHA6 protein (UniProt Q9Y2H5) is 1048 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9Y2H5 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9Y2H5 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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