Microtubule-associated serine/threonine-protein kinase 1 (MAST1)
Homo sapiens — UniProt Q9Y2H9
Data last refreshed: (UniProt release unknown)
Key facts
Microtubule-associated serine/threonine-protein kinase 1 (MAST1) is a protein from Homo sapiens identified by UniProt accession Q9Y2H9, 1570 residues long. MolForge cross-references it against 6 known binders and 52 disease associations.
- UniProt accession: Q9Y2H9; gene symbol MAST1.
- Organism: Homo sapiens.
- Length: 1570 amino acids.
- Top disease associations (Open Targets): mega-corpus-callosum syndrome with cerebellar hypoplasia and cortical malformations, neurodegenerative disease and mathematical ability.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Microtubule-associated serine/threonine-protein kinase 1 |
|---|---|
| UniProt accession | Q9Y2H9 |
| Gene | MAST1 |
| Organism | Homo sapiens |
| Length | 1570 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (52)
Diseases linked to this target (Open Targets).
- mega-corpus-callosum syndrome with cerebellar hypoplasia and cortical malformations · score 0.72
- neurodegenerative disease · score 0.37
- mathematical ability · score 0.27
- monocyte count · score 0.24
- genetic disorder · score 0.19
- cognitive function measurement · score 0.19
- Immature Reticulocyte Fraction Measurement · score 0.17
- mean corpuscular hemoglobin concentration · score 0.16
- mean corpuscular volume · score 0.15
- reticulocyte count · score 0.15
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9Y2H9-F1 | alphafold | PREDICTED | 53.23 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9Y2H9.
Amino-acid sequence (1570 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with MAST1?
The strongest Open Targets associations for MAST1 are mega-corpus-callosum syndrome with cerebellar hypoplasia and cortical malformations, neurodegenerative disease, mathematical ability, monocyte count and genetic disorder.
How long is the MAST1 protein?
The Homo sapiens MAST1 protein (UniProt Q9Y2H9) is 1570 amino acids long.
Browse: Targets: M · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9Y2H9 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9Y2H9 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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