Rabphilin-3A (RPH3A)
Homo sapiens — UniProt Q9Y2J0
Data last refreshed: (UniProt release unknown)
Key facts
Rabphilin-3A (RPH3A) is a protein from Homo sapiens identified by UniProt accession Q9Y2J0, 694 residues long. MolForge cross-references it against 0 known binders and 112 disease associations.
- UniProt accession: Q9Y2J0; gene symbol RPH3A.
- Organism: Homo sapiens.
- Length: 694 amino acids.
- Top disease associations (Open Targets): low density lipoprotein cholesterol measurement, platelet count and eosinophil count.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Rabphilin-3A |
|---|---|
| UniProt accession | Q9Y2J0 |
| Gene | RPH3A |
| Organism | Homo sapiens |
| Length | 694 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (112)
Diseases linked to this target (Open Targets).
- low density lipoprotein cholesterol measurement · score 0.42
- platelet count · score 0.38
- eosinophil count · score 0.38
- body weight · score 0.37
- urate measurement · score 0.36
- smoking status measurement · score 0.35
- reticulocyte count · score 0.34
- apolipoprotein B measurement · score 0.30
- von Willebrand factor measurement · score 0.29
- alcohol consumption measurement · score 0.29
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9Y2J0-F1 | alphafold | PREDICTED | 68.76 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9Y2J0.
Amino-acid sequence (694 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with RPH3A?
The strongest Open Targets associations for RPH3A are low density lipoprotein cholesterol measurement, platelet count, eosinophil count, body weight and urate measurement.
How long is the RPH3A protein?
The Homo sapiens RPH3A protein (UniProt Q9Y2J0) is 694 amino acids long.
Browse: Targets: R · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9Y2J0 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9Y2J0 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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