Angiomotin-like protein 2 (AMOTL2)
Homo sapiens — UniProt Q9Y2J4
Data last refreshed: (UniProt release unknown)
Key facts
Angiomotin-like protein 2 (AMOTL2) is a protein from Homo sapiens identified by UniProt accession Q9Y2J4, 779 residues long. MolForge cross-references it against 0 known binders and 53 disease associations.
- UniProt accession: Q9Y2J4; gene symbol AMOTL2.
- Organism: Homo sapiens.
- Length: 779 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, diastolic blood pressure and age at onset.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Angiomotin-like protein 2 |
|---|---|
| UniProt accession | Q9Y2J4 |
| Gene | AMOTL2 |
| Organism | Homo sapiens |
| Length | 779 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (53)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.53
- diastolic blood pressure · score 0.39
- age at onset · score 0.38
- Myopia · score 0.38
- reticulocyte measurement · score 0.37
- refractive error · score 0.31
- reticulocyte count · score 0.27
- PHF-tau measurement · score 0.24
- systolic blood pressure · score 0.18
- lean body mass · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9Y2J4-F1 | alphafold | PREDICTED | 65.85 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9Y2J4.
Amino-acid sequence (779 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with AMOTL2?
The strongest Open Targets associations for AMOTL2 are neurodegenerative disease, diastolic blood pressure, age at onset, Myopia and reticulocyte measurement.
How long is the AMOTL2 protein?
The Homo sapiens AMOTL2 protein (UniProt Q9Y2J4) is 779 amino acids long.
Browse: Targets: A · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9Y2J4 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9Y2J4 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.