Protein-arginine deiminase type-2 (PADI2)
Homo sapiens — UniProt Q9Y2J8
Data last refreshed: (UniProt release unknown)
Key facts
Protein-arginine deiminase type-2 (PADI2) is a protein from Homo sapiens identified by UniProt accession Q9Y2J8, 665 residues long. MolForge cross-references it against 0 known binders and 199 disease associations.
- UniProt accession: Q9Y2J8; gene symbol PADI2.
- Organism: Homo sapiens.
- Length: 665 amino acids.
- Top disease associations (Open Targets): rheumatoid arthritis, interstitial lung disease and Abnormal pulmonary interstitial morphology.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Protein-arginine deiminase type-2 |
|---|---|
| UniProt accession | Q9Y2J8 |
| Gene | PADI2 |
| Organism | Homo sapiens |
| Length | 665 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (199)
Diseases linked to this target (Open Targets).
- rheumatoid arthritis · score 0.56
- interstitial lung disease · score 0.50
- Abnormal pulmonary interstitial morphology · score 0.47
- Paraganglioma · score 0.33
- neurodegenerative disease · score 0.28
- hemoglobin measurement · score 0.25
- breast adenocarcinoma · score 0.22
- hematocrit · score 0.17
- Rheumatoid arthritis · score 0.11
- neoplasm · score 0.10
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9Y2J8-F1 | alphafold | PREDICTED | 94.27 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9Y2J8.
Amino-acid sequence (665 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with PADI2?
The strongest Open Targets associations for PADI2 are rheumatoid arthritis, interstitial lung disease, Abnormal pulmonary interstitial morphology, Paraganglioma and neurodegenerative disease.
How long is the PADI2 protein?
The Homo sapiens PADI2 protein (UniProt Q9Y2J8) is 665 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9Y2J8 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9Y2J8 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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