Zinc finger and BTB domain-containing protein 1 (ZBTB1)
Homo sapiens — UniProt Q9Y2K1
Data last refreshed: (UniProt release unknown)
Key facts
Zinc finger and BTB domain-containing protein 1 (ZBTB1) is a protein from Homo sapiens identified by UniProt accession Q9Y2K1, 713 residues long. MolForge cross-references it against 0 known binders and 155 disease associations.
- UniProt accession: Q9Y2K1; gene symbol ZBTB1.
- Organism: Homo sapiens.
- Length: 713 amino acids.
- Top disease associations (Open Targets): IGF-1 measurement, lymphocyte count and neurodegenerative disease.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Zinc finger and BTB domain-containing protein 1 |
|---|---|
| UniProt accession | Q9Y2K1 |
| Gene | ZBTB1 |
| Organism | Homo sapiens |
| Length | 713 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (155)
Diseases linked to this target (Open Targets).
- IGF-1 measurement · score 0.21
- lymphocyte count · score 0.18
- neurodegenerative disease · score 0.16
- platelet-to-lymphocyte ratio · score 0.13
- platelet count · score 0.10
- heel bone mineral density · score 0.10
- self reported educational attainment · score 0.09
- lymphocyte percentage of leukocytes · score 0.08
- neutrophil percentage of leukocytes · score 0.07
- mean corpuscular hemoglobin · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9Y2K1-F1 | alphafold | PREDICTED | 54.16 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9Y2K1.
Amino-acid sequence (713 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with ZBTB1?
The strongest Open Targets associations for ZBTB1 are IGF-1 measurement, lymphocyte count, neurodegenerative disease, platelet-to-lymphocyte ratio and platelet count.
How long is the ZBTB1 protein?
The Homo sapiens ZBTB1 protein (UniProt Q9Y2K1) is 713 amino acids long.
Browse: Targets: Z · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9Y2K1 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9Y2K1 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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