Myosin-15 (MYH15)

Homo sapiens — UniProt Q9Y2K3

Gene: MYH15Homo sapiensSwissProt reviewed

Data last refreshed: 2026-04-18 (UniProt release unknown)

Key facts

Myosin-15 (MYH15) is a protein from Homo sapiens identified by UniProt accession Q9Y2K3, 1926 residues long. MolForge cross-references it against 0 known binders and 56 disease associations.

UniProt accession: Q9Y2K3; gene symbol MYH15.
Organism: Homo sapiens.
Length: 1926 amino acids.
Top disease associations (Open Targets): body mass index, self reported educational attainment and hypothyroidism.
3D structure: AlphaFold model available.

Target properties

Protein name	Myosin-15
UniProt accession	Q9Y2K3
Gene	MYH15
Organism	Homo sapiens
Length	1926 residues
Molecular weight	—
EC numbers	—
Target class	—
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (56)

Diseases linked to this target (Open Targets).

body mass index · score 0.39
self reported educational attainment · score 0.36
hypothyroidism · score 0.34
bipolar disorder · score 0.30
unipolar depression · score 0.30
body fat percentage · score 0.30
anxiety disorder · score 0.29
thyroid disease · score 0.27
intelligence · score 0.25
cognitive function measurement · score 0.20

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9Y2K3-F1	alphafold	PREDICTED	74.51	—

Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9Y2K3.

Amino-acid sequence (1926 residues)

MDLSDLGEAA AFLRRSEAEL LLLQATALDG KKKCWIPDGE NAYIEAEVKG SEDDGTVIVE TADGESLSIK EDKIQQMNPP EFEMIEDMAM LTHLNEASVL HTLKRRYGQW MIYTYSGLFC VTINPYKWLP VYQKEVMAAY KGKRRSEAPP HIFAVANNAF QDMLHNRENQ SILFTGESGA GKTVNSKHII QYFATIAAMI ESRKKQGALE DQIMQANTIL EAFGNAKTLR NDNSSRFGKF IRMHFGARGM LSSVDIDIYL LEKSRVIFQQ AGERNYHIFY QILSGQKELH DLLLVSANPS DFHFCSCGAV TVESLDDAEE LLATEQAMDI LGFLPDEKYG CYKLTGAIMH FGNMKFKQKP REEQLEADGT ENADKAAFLM GINSSELVKC LIHPRIKVGN EYVTRGQTIE QVTCAVGALS KSMYERMFKW LVARINRALD AKLSRQFFIG ILDITGFEIL EYNSLEQLCI NFTNEKLQQF FNWHMFVLEQ EEYKKESIEW VSIGFGLDLQ ACIDLIEKPM GILSILEEEC MFPKATDLTF KTKLFDNHFG KSVHLQKPKP DKKKFEAHFE LVHYAGVVPY NISGWLEKNK DLLNETVVAV FQKSSNRLLA SLFENYMSTD SAIPFGEKKR KKGASFQTVA SLHKENLNKL MTNLKSTAPH FVRCINPNVN KIPGILDPYL VLQQLRCNGV LEGTRICREG FPNRLQYADF KQRYCILNPR TFPKSKFVSS RKAAEELLGS LEIDHTQYRF GITKVFFKAG FLGQLEAIRD ERLSKVFTLF QARAQGKLMR IKFQKILEER DALILIQWNI RAFMAVKNWP WMRLFFKIKP LVKSSEVGEE VAGLKEECAQ LQKALEKSEF QREELKAKQV SLTQEKNDLI LQLQAEQETL ANVEEQCEWL IKSKIQLEAR VKELSERVEE EEEINSELTA RGRKLEDECF ELKKEIDDLE TMLVKSEKEK RTTEHKVKNL TEEVEFLNED ISKLNRAAKV VQEAHQQTLD DLHMEEEKLS SLSKANLKLE QQVDELEGAL EQERKARMNC ERELHKLEGN LKLNRESMEN LESSQRHLAE ELRKKELELS QMNSKVENEK GLVAQLQKTV KELQTQIKDL KEKLEAERTT RAKMERERAD LTQDLADLNE RLEEVGGSSL AQLEITKKQE TKFQKLHRDM EEATLHFETT SASLKKRHAD SLAELEGQVE NLQQVKQKLE KDKSDLQLEV DDLLTRVEQM TRAKANAEKL CTLYEERLHE ATAKLDKVTQ LANDLAAQKT KLWSESGEFL RRLEEKEALI NQLSREKSNF TRQIEDLRGQ LEKETKSQSA LAHALQKAQR DCDLLREQYE EEQEVKAELH RTLSKVNAEM VQWRMKYENN VIQRTEDLED AKKELAIRLQ EAAEAMGVAN ARNASLERAR HQLQLELGDA LSDLGKVRSA AARLDQKQLQ SGKALADWKQ KHEESQALLD ASQKEVQALS TELLKLKNTY EESIVGQETL RRENKNLQEE ISNLTNQVRE GTKNLTEMEK VKKLIEEEKT EVQVTLEETE GALERNESKI LHFQLELLEA KAELERKLSE KDEEIENFRR KQQCTIDSLQ SSLDSEAKSR IEVTRLKKKM EEDLNEMELQ LSCANRQVSE ATKSLGQLQI QIKDLQMQLD DSTQLNSDLK EQVAVAERRN SLLQSELEDL RSLQEQTERG RRLSEEELLE ATERINLFYT QNTSLLSQKK KLEADVARMQ KEAEEVVQEC QNAEEKAKKA AIEAANLSEE LKKKQDTIAH LERTRENMEQ TITDLQKRLA EAEQMALMGS RKQIQKLESR VRELEGELEG EIRRSAEAQR GARRLERCIK ELTYQAEEDK KNLSRMQTQM DKLQLKVQNY KQQVEVAETQ ANQYLSKYKK QQHELNEVKE RAEVAESQVN KLKIKAREFG KKVQEE

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards

Frequently asked questions

Answers are generated from the structured data on this page, not written by hand.

Which diseases are associated with MYH15?

The strongest Open Targets associations for MYH15 are body mass index, self reported educational attainment, hypothyroidism, bipolar disorder and unipolar depression.

How long is the MYH15 protein?

The Homo sapiens MYH15 protein (UniProt Q9Y2K3) is 1926 amino acids long.

Browse: Targets: M · all protein targets A–Z · drugs A–Z.

Sources

UniProtKB Q9Y2K3 — name, gene, function, sequence, keywords (CC BY 4.0)
AlphaFold DB Q9Y2K3 — predicted 3D structure (CC BY 4.0)
Open Targets Platform — disease associations and tractability (CC0)

How this page is built: methodology · editorial policy & corrections.

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