Ubiquitin carboxyl-terminal hydrolase 20 (USP20)
Homo sapiens — UniProt Q9Y2K6
Data last refreshed: (UniProt release unknown)
Key facts
Ubiquitin carboxyl-terminal hydrolase 20 (USP20) is a protein from Homo sapiens identified by UniProt accession Q9Y2K6, 914 residues long. MolForge cross-references it against 0 known binders and 75 disease associations.
- UniProt accession: Q9Y2K6; gene symbol USP20.
- Organism: Homo sapiens.
- Length: 914 amino acids.
- Top disease associations (Open Targets): pancreatic adenocarcinoma, glioblastoma multiforme and ovarian cancer.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Ubiquitin carboxyl-terminal hydrolase 20 |
|---|---|
| UniProt accession | Q9Y2K6 |
| Gene | USP20 |
| Organism | Homo sapiens |
| Length | 914 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (75)
Diseases linked to this target (Open Targets).
- pancreatic adenocarcinoma · score 0.26
- glioblastoma multiforme · score 0.23
- ovarian cancer · score 0.23
- breast adenocarcinoma · score 0.23
- neurodegenerative disease · score 0.21
- protein measurement · score 0.19
- cystatin C measurement · score 0.15
- creatinine measurement · score 0.14
- amyloidosis · score 0.12
- esophageal cancer · score 0.10
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9Y2K6-F1 | alphafold | PREDICTED | 72.33 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9Y2K6.
Amino-acid sequence (914 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with USP20?
The strongest Open Targets associations for USP20 are pancreatic adenocarcinoma, glioblastoma multiforme, ovarian cancer, breast adenocarcinoma and neurodegenerative disease.
How long is the USP20 protein?
The Homo sapiens USP20 protein (UniProt Q9Y2K6) is 914 amino acids long.
Browse: Targets: U · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9Y2K6 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9Y2K6 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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