Exosome complex exonuclease RRP44 (DIS3)
Homo sapiens — UniProt Q9Y2L1
Data last refreshed: (UniProt release unknown)
Key facts
Exosome complex exonuclease RRP44 (DIS3) is a protein from Homo sapiens identified by UniProt accession Q9Y2L1, 958 residues long. MolForge cross-references it against 0 known binders and 70 disease associations.
- UniProt accession: Q9Y2L1; gene symbol DIS3.
- Organism: Homo sapiens.
- Length: 958 amino acids.
- Top disease associations (Open Targets): multiple myeloma, Perlman syndrome and body height.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Exosome complex exonuclease RRP44 |
|---|---|
| UniProt accession | Q9Y2L1 |
| Gene | DIS3 |
| Organism | Homo sapiens |
| Length | 958 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (70)
Diseases linked to this target (Open Targets).
- multiple myeloma · score 0.44
- Perlman syndrome · score 0.12
- body height · score 0.11
- mean corpuscular volume · score 0.10
- breast adenocarcinoma · score 0.10
- cerebellar volume measurement · score 0.10
- systolic blood pressure · score 0.10
- creatinine measurement · score 0.10
- gout · score 0.09
- testosterone measurement · score 0.09
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9Y2L1-F1 | alphafold | PREDICTED | 85.92 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9Y2L1.
Amino-acid sequence (958 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with DIS3?
The strongest Open Targets associations for DIS3 are multiple myeloma, Perlman syndrome, body height, mean corpuscular volume and breast adenocarcinoma.
How long is the DIS3 protein?
The Homo sapiens DIS3 protein (UniProt Q9Y2L1) is 958 amino acids long.
Browse: Targets: D · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9Y2L1 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9Y2L1 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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