FERM domain-containing protein 4B (FRMD4B)
Homo sapiens — UniProt Q9Y2L6
Data last refreshed: (UniProt release unknown)
Key facts
FERM domain-containing protein 4B (FRMD4B) is a protein from Homo sapiens identified by UniProt accession Q9Y2L6, 1034 residues long. MolForge cross-references it against 0 known binders and 68 disease associations.
- UniProt accession: Q9Y2L6; gene symbol FRMD4B.
- Organism: Homo sapiens.
- Length: 1034 amino acids.
- Top disease associations (Open Targets): PR interval, cortical thickness and atrial fibrillation.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | FERM domain-containing protein 4B |
|---|---|
| UniProt accession | Q9Y2L6 |
| Gene | FRMD4B |
| Organism | Homo sapiens |
| Length | 1034 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (68)
Diseases linked to this target (Open Targets).
- PR interval · score 0.36
- cortical thickness · score 0.36
- atrial fibrillation · score 0.35
- cortical surface area measurement · score 0.33
- retinal nerve fibre layer thickness measurement · score 0.30
- retinal layer thickness measurement · score 0.30
- diet measurement · score 0.30
- resting heart rate · score 0.29
- brain measurement · score 0.29
- neurofibrillary tangles measurement · score 0.28
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9Y2L6-F1 | alphafold | PREDICTED | 62.17 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9Y2L6.
Amino-acid sequence (1034 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with FRMD4B?
The strongest Open Targets associations for FRMD4B are PR interval, cortical thickness, atrial fibrillation, cortical surface area measurement and retinal nerve fibre layer thickness measurement.
How long is the FRMD4B protein?
The Homo sapiens FRMD4B protein (UniProt Q9Y2L6) is 1034 amino acids long.
Browse: Targets: F · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9Y2L6 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9Y2L6 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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