Leucine-rich repeat and calponin homology domain-containing protein 1 (LRCH1)
Homo sapiens — UniProt Q9Y2L9
Data last refreshed: (UniProt release unknown)
Key facts
Leucine-rich repeat and calponin homology domain-containing protein 1 (LRCH1) is a protein from Homo sapiens identified by UniProt accession Q9Y2L9, 728 residues long. MolForge cross-references it against 0 known binders and 71 disease associations.
- UniProt accession: Q9Y2L9; gene symbol LRCH1.
- Organism: Homo sapiens.
- Length: 728 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, mean platelet volume and platelet count.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Leucine-rich repeat and calponin homology domain-containing protein 1 |
|---|---|
| UniProt accession | Q9Y2L9 |
| Gene | LRCH1 |
| Organism | Homo sapiens |
| Length | 728 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (71)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.46
- mean platelet volume · score 0.43
- platelet count · score 0.43
- platelet component distribution width · score 0.41
- PR interval · score 0.39
- pulse pressure measurement · score 0.38
- cortical surface area measurement · score 0.37
- brain measurement · score 0.36
- electrocardiography · score 0.36
- adolescent idiopathic scoliosis · score 0.35
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9Y2L9-F1 | alphafold | PREDICTED | 62.77 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9Y2L9.
Amino-acid sequence (728 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with LRCH1?
The strongest Open Targets associations for LRCH1 are neurodegenerative disease, mean platelet volume, platelet count, platelet component distribution width and PR interval.
How long is the LRCH1 protein?
The Homo sapiens LRCH1 protein (UniProt Q9Y2L9) is 728 amino acids long.
Browse: Targets: L · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9Y2L9 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9Y2L9 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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