Fanconi-associated nuclease 1 (FAN1)
Homo sapiens — UniProt Q9Y2M0
Data last refreshed: (UniProt release unknown)
Key facts
Fanconi-associated nuclease 1 (FAN1) is a protein from Homo sapiens identified by UniProt accession Q9Y2M0, 1017 residues long. MolForge cross-references it against 0 known binders and 41 disease associations.
- UniProt accession: Q9Y2M0; gene symbol FAN1.
- Organism: Homo sapiens.
- Length: 1017 amino acids.
- Top disease associations (Open Targets): karyomegalic interstitial nephritis, chronic kidney disease and interstitial nephritis.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Fanconi-associated nuclease 1 |
|---|---|
| UniProt accession | Q9Y2M0 |
| Gene | FAN1 |
| Organism | Homo sapiens |
| Length | 1017 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (41)
Diseases linked to this target (Open Targets).
- karyomegalic interstitial nephritis · score 0.76
- chronic kidney disease · score 0.46
- interstitial nephritis · score 0.46
- neurodegenerative disease · score 0.33
- genetic disorder · score 0.19
- low grade glioma · score 0.18
- breast adenocarcinoma · score 0.18
- Hereditary breast and ovarian cancer syndrome · score 0.15
- hereditary breast ovarian cancer syndrome · score 0.15
- familial juvenile hyperuricemic nephropathy type 1 · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9Y2M0-F1 | alphafold | PREDICTED | 69.86 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9Y2M0.
Amino-acid sequence (1017 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with FAN1?
The strongest Open Targets associations for FAN1 are karyomegalic interstitial nephritis, chronic kidney disease, interstitial nephritis, neurodegenerative disease and genetic disorder.
How long is the FAN1 protein?
The Homo sapiens FAN1 protein (UniProt Q9Y2M0) is 1017 amino acids long.
Browse: Targets: F · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9Y2M0 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9Y2M0 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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