Hypoxia-inducible factor 3-alpha (HIF3A)
Homo sapiens — UniProt Q9Y2N7
Data last refreshed: (UniProt release unknown)
Key facts
Hypoxia-inducible factor 3-alpha (HIF3A) is a protein from Homo sapiens identified by UniProt accession Q9Y2N7, 669 residues long. MolForge cross-references it against 0 known binders and 158 disease associations.
- UniProt accession: Q9Y2N7; gene symbol HIF3A.
- Organism: Homo sapiens.
- Length: 669 amino acids.
- Top disease associations (Open Targets): very low density lipoprotein cholesterol measurement, triglyceride measurement and phospholipid measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Hypoxia-inducible factor 3-alpha |
|---|---|
| UniProt accession | Q9Y2N7 |
| Gene | HIF3A |
| Organism | Homo sapiens |
| Length | 669 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (158)
Diseases linked to this target (Open Targets).
- very low density lipoprotein cholesterol measurement · score 0.30
- triglyceride measurement · score 0.28
- phospholipid measurement · score 0.27
- clear cell renal carcinoma · score 0.25
- free cholesterol measurement · score 0.20
- breast adenocarcinoma · score 0.18
- head and neck squamous cell carcinoma · score 0.18
- low grade glioma · score 0.17
- urinary bladder cancer · score 0.11
- gestational diabetes · score 0.09
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9Y2N7-F1 | alphafold | PREDICTED | 65.10 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9Y2N7.
Amino-acid sequence (669 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with HIF3A?
The strongest Open Targets associations for HIF3A are very low density lipoprotein cholesterol measurement, triglyceride measurement, phospholipid measurement, clear cell renal carcinoma and free cholesterol measurement.
How long is the HIF3A protein?
The Homo sapiens HIF3A protein (UniProt Q9Y2N7) is 669 amino acids long.
Browse: Targets: H · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9Y2N7 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9Y2N7 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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