Phospholipid-transporting ATPase IA (ATP8A1)
Homo sapiens — UniProt Q9Y2Q0
Data last refreshed: (UniProt release unknown)
Key facts
Phospholipid-transporting ATPase IA (ATP8A1) is a protein from Homo sapiens identified by UniProt accession Q9Y2Q0, 1164 residues long. MolForge cross-references it against 0 known binders and 80 disease associations.
- UniProt accession: Q9Y2Q0; gene symbol ATP8A1.
- Organism: Homo sapiens.
- Length: 1164 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, neurofibrillary tangles measurement and blood protein measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Phospholipid-transporting ATPase IA |
|---|---|
| UniProt accession | Q9Y2Q0 |
| Gene | ATP8A1 |
| Organism | Homo sapiens |
| Length | 1164 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (80)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.32
- neurofibrillary tangles measurement · score 0.26
- blood protein measurement · score 0.19
- snoring measurement · score 0.18
- lymphocyte percentage of leukocytes · score 0.17
- Snoring · score 0.15
- glioblastoma multiforme · score 0.15
- appendicular lean mass · score 0.11
- breast adenocarcinoma · score 0.10
- hemoglobin D disease · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9Y2Q0-F1 | alphafold | PREDICTED | 82.41 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9Y2Q0.
Amino-acid sequence (1164 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with ATP8A1?
The strongest Open Targets associations for ATP8A1 are neurodegenerative disease, neurofibrillary tangles measurement, blood protein measurement, snoring measurement and lymphocyte percentage of leukocytes.
How long is the ATP8A1 protein?
The Homo sapiens ATP8A1 protein (UniProt Q9Y2Q0) is 1164 amino acids long.
Browse: Targets: A · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9Y2Q0 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9Y2Q0 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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