Glutathione S-transferase kappa 1 (GSTK1)
Homo sapiens — UniProt Q9Y2Q3
Data last refreshed: (UniProt release unknown)
Key facts
Glutathione S-transferase kappa 1 (GSTK1) is a protein from Homo sapiens identified by UniProt accession Q9Y2Q3, 226 residues long. MolForge cross-references it against 1 known binders and 71 disease associations.
- UniProt accession: Q9Y2Q3; gene symbol GSTK1.
- Organism: Homo sapiens.
- Length: 226 amino acids.
- Top disease associations (Open Targets): glioblastoma multiforme, blood protein measurement and neoplasm.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Glutathione S-transferase kappa 1 |
|---|---|
| UniProt accession | Q9Y2Q3 |
| Gene | GSTK1 |
| Organism | Homo sapiens |
| Length | 226 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (71)
Diseases linked to this target (Open Targets).
- glioblastoma multiforme · score 0.16
- blood protein measurement · score 0.06
- neoplasm · score 0.06
- nephrotic syndrome · score 0.05
- hypertrophic cardiomyopathy · score 0.05
- familial idiopathic steroid-resistant nephrotic syndrome · score 0.04
- cancer · score 0.04
- nephronophthisis · score 0.04
- renal dysplasia · score 0.04
- C3 glomerulonephritis · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9Y2Q3-F1 | alphafold | PREDICTED | 95.46 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9Y2Q3.
Amino-acid sequence (226 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with GSTK1?
The strongest Open Targets associations for GSTK1 are glioblastoma multiforme, blood protein measurement, neoplasm, nephrotic syndrome and hypertrophic cardiomyopathy.
How long is the GSTK1 protein?
The Homo sapiens GSTK1 protein (UniProt Q9Y2Q3) is 226 amino acids long.
Browse: Targets: G · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9Y2Q3 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9Y2Q3 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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