Ragulator complex protein LAMTOR2 (LAMTOR2)
Homo sapiens — UniProt Q9Y2Q5
Data last refreshed: (UniProt release unknown)
Key facts
Ragulator complex protein LAMTOR2 (LAMTOR2) is a protein from Homo sapiens identified by UniProt accession Q9Y2Q5, 125 residues long. MolForge cross-references it against 0 known binders and 44 disease associations.
- UniProt accession: Q9Y2Q5; gene symbol LAMTOR2.
- Organism: Homo sapiens.
- Length: 125 amino acids.
- Top disease associations (Open Targets): primary immunodeficiency syndrome due to p14 deficiency, constitutional neutropenia and glioblastoma multiforme.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Ragulator complex protein LAMTOR2 |
|---|---|
| UniProt accession | Q9Y2Q5 |
| Gene | LAMTOR2 |
| Organism | Homo sapiens |
| Length | 125 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (44)
Diseases linked to this target (Open Targets).
- primary immunodeficiency syndrome due to p14 deficiency · score 0.70
- constitutional neutropenia · score 0.46
- glioblastoma multiforme · score 0.30
- neurodegenerative disease · score 0.29
- breast adenocarcinoma · score 0.29
- lung adenocarcinoma · score 0.28
- squamous cell lung carcinoma · score 0.18
- clear cell renal carcinoma · score 0.14
- prostate adenocarcinoma · score 0.09
- hematocrit · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9Y2Q5-F1 | alphafold | PREDICTED | 91.42 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9Y2Q5.
Amino-acid sequence (125 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with LAMTOR2?
The strongest Open Targets associations for LAMTOR2 are primary immunodeficiency syndrome due to p14 deficiency, constitutional neutropenia, glioblastoma multiforme, neurodegenerative disease and breast adenocarcinoma.
How long is the LAMTOR2 protein?
The Homo sapiens LAMTOR2 protein (UniProt Q9Y2Q5) is 125 amino acids long.
Browse: Targets: L · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9Y2Q5 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9Y2Q5 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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