Cytochrome c oxidase assembly factor 3 homolog, mitochondrial (COA3)
Homo sapiens — UniProt Q9Y2R0
Data last refreshed: (UniProt release unknown)
Key facts
Cytochrome c oxidase assembly factor 3 homolog, mitochondrial (COA3) is a protein from Homo sapiens identified by UniProt accession Q9Y2R0, 106 residues long. MolForge cross-references it against 0 known binders and 33 disease associations.
- UniProt accession: Q9Y2R0; gene symbol COA3.
- Organism: Homo sapiens.
- Length: 106 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, leigh syndrome due to mitochondrial complex iv deficiency and mitochondrial complex IV deficiency, nuclear type 22.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Cytochrome c oxidase assembly factor 3 homolog, mitochondrial |
|---|---|
| UniProt accession | Q9Y2R0 |
| Gene | COA3 |
| Organism | Homo sapiens |
| Length | 106 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (33)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.54
- leigh syndrome due to mitochondrial complex iv deficiency · score 0.42
- mitochondrial complex IV deficiency, nuclear type 22 · score 0.42
- mitochondrial complex 4 deficiency, nuclear type 14 · score 0.41
- Isolated cytochrome C oxidase deficiency · score 0.37
- BMI-adjusted waist circumference · score 0.04
- pulse pressure measurement · score 0.03
- non-small cell lung carcinoma · score 0.03
- systemic juvenile idiopathic arthritis · score 0.01
- neuropathy · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9Y2R0-F1 | alphafold | PREDICTED | 77.38 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9Y2R0.
Amino-acid sequence (106 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with COA3?
The strongest Open Targets associations for COA3 are neurodegenerative disease, leigh syndrome due to mitochondrial complex iv deficiency, mitochondrial complex IV deficiency, nuclear type 22, mitochondrial complex 4 deficiency, nuclear type 14 and Isolated cytochrome C oxidase deficiency.
How long is the COA3 protein?
The Homo sapiens COA3 protein (UniProt Q9Y2R0) is 106 amino acids long.
Browse: Targets: C · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9Y2R0 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9Y2R0 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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