Probable ATP-dependent RNA helicase DDX52 (DDX52)
Homo sapiens — UniProt Q9Y2R4
Data last refreshed: (UniProt release unknown)
Key facts
Probable ATP-dependent RNA helicase DDX52 (DDX52) is a protein from Homo sapiens identified by UniProt accession Q9Y2R4, 599 residues long. MolForge cross-references it against 0 known binders and 31 disease associations.
- UniProt accession: Q9Y2R4; gene symbol DDX52.
- Organism: Homo sapiens.
- Length: 599 amino acids.
- Top disease associations (Open Targets): type 2 diabetes mellitus, Miyoshi myopathy and diabetes mellitus.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Probable ATP-dependent RNA helicase DDX52 |
|---|---|
| UniProt accession | Q9Y2R4 |
| Gene | DDX52 |
| Organism | Homo sapiens |
| Length | 599 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (31)
Diseases linked to this target (Open Targets).
- type 2 diabetes mellitus · score 0.08
- Miyoshi myopathy · score 0.07
- diabetes mellitus · score 0.07
- blood urea nitrogen measurement · score 0.07
- cognitive function measurement · score 0.07
- drug use measurement · score 0.06
- C-reactive protein measurement · score 0.06
- lung adenocarcinoma · score 0.06
- complication · score 0.06
- HbA1c measurement · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9Y2R4-F1 | alphafold | PREDICTED | 76.58 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9Y2R4.
Amino-acid sequence (599 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with DDX52?
The strongest Open Targets associations for DDX52 are type 2 diabetes mellitus, Miyoshi myopathy, diabetes mellitus, blood urea nitrogen measurement and cognitive function measurement.
How long is the DDX52 protein?
The Homo sapiens DDX52 protein (UniProt Q9Y2R4) is 599 amino acids long.
Browse: Targets: D · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9Y2R4 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9Y2R4 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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