Polymerase delta-interacting protein 2 (POLDIP2)

About Polymerase delta-interacting protein 2

Polymerase delta-interacting protein 2 (POLDIP2) is a protein from Homo sapiens identified by UniProt accession Q9Y2S7, 368 residues long. MolForge cross-references it against 0 known binders and 103 disease associations.

Target properties

Protein name	Polymerase delta-interacting protein 2
UniProt accession	Q9Y2S7
Gene	POLDIP2
Organism	Homo sapiens
Length	368 residues
Molecular weight	—
EC numbers	—
Target class	—
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (103)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.33
blood protein measurement · score 0.16
low density lipoprotein cholesterol measurement · score 0.12
age-related macular degeneration · score 0.11
apolipoprotein A 1 measurement · score 0.10
triglyceride measurement · score 0.10
atrophic macular degeneration · score 0.09
wet macular degeneration · score 0.09
high density lipoprotein cholesterol measurement · score 0.09
systolic blood pressure · score 0.08

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9Y2S7-F1	alphafold	PREDICTED	79.78	—

Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9Y2S7.

Amino-acid sequence (368 residues)

MAACTARRAL AVGSRWWSRS LTGARWPRPL CAAAGAGAFS PASTTTTRRH LSSRNRPEGK VLETVGVFEV PKQNGKYETG QLFLHSIFGY RGVVLFPWQA RLYDRDVASA APEKAENPAG HGSKEVKGKT HTYYQVLIDA RDCPHISQRS QTEAVTFLAN HDDSRALYAI PGLDYVSHED ILPYTSTDQV PIQHELFERF LLYDQTKAPP FVARETLRAW QEKNHPWLEL SDVHRETTEN IRVTVIPFYM GMREAQNSHV YWWRYCIRLE NLDSDVVQLR ERHWRIFSLS GTLETVRGRG VVGREPVLSK EQPAFQYSSH VSLQASSGHM WGTFRFERPD GSHFDVRIPP FSLESNKDEK TPPSGLHW

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards