Axin-2 (AXIN2)
Homo sapiens — UniProt Q9Y2T1
Data last refreshed: (UniProt release unknown)
Key facts
Axin-2 (AXIN2) is a protein from Homo sapiens identified by UniProt accession Q9Y2T1, 843 residues long. MolForge cross-references it against 0 known binders and 422 disease associations.
- UniProt accession: Q9Y2T1; gene symbol AXIN2.
- Organism: Homo sapiens.
- Length: 843 amino acids.
- Top disease associations (Open Targets): oligodontia-cancer predisposition syndrome, Oligodontia - cancer predisposition syndrome and colorectal cancer.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Axin-2 |
|---|---|
| UniProt accession | Q9Y2T1 |
| Gene | AXIN2 |
| Organism | Homo sapiens |
| Length | 843 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (422)
Diseases linked to this target (Open Targets).
- oligodontia-cancer predisposition syndrome · score 0.76
- Oligodontia - cancer predisposition syndrome · score 0.67
- colorectal cancer · score 0.62
- AXIN2-related attenuated familial adenomatous polyposis · score 0.61
- hereditary neoplastic syndrome · score 0.56
- Inherited cancer-predisposing syndrome · score 0.56
- tooth agenesis · score 0.53
- heel bone mineral density · score 0.48
- body height · score 0.48
- colon carcinoma · score 0.46
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9Y2T1-F1 | alphafold | PREDICTED | 60.50 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9Y2T1.
Amino-acid sequence (843 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with AXIN2?
The strongest Open Targets associations for AXIN2 are oligodontia-cancer predisposition syndrome, Oligodontia - cancer predisposition syndrome, colorectal cancer, AXIN2-related attenuated familial adenomatous polyposis and hereditary neoplastic syndrome.
How long is the AXIN2 protein?
The Homo sapiens AXIN2 protein (UniProt Q9Y2T1) is 843 amino acids long.
Browse: Targets: A · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9Y2T1 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9Y2T1 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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