Guanine deaminase (GDA)

About Guanine deaminase

Guanine deaminase (GDA) is a protein from Homo sapiens identified by UniProt accession Q9Y2T3, 454 residues long. MolForge cross-references it against 1 known binders and 97 disease associations.

Target properties

Protein name	Guanine deaminase
UniProt accession	Q9Y2T3
Gene	GDA
Organism	Homo sapiens
Length	454 residues
Molecular weight	—
EC numbers	—
Target class	—
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (97)

Diseases linked to this target (Open Targets).

urate measurement · score 0.43
cutaneous melanoma · score 0.18
triple-negative breast cancer · score 0.09
non-small cell lung carcinoma · score 0.08
adolescent idiopathic scoliosis · score 0.08
retinopathy · score 0.07
optic choroid disorder · score 0.07
psoriasis · score 0.07
Barrett's esophagus · score 0.06
serum albumin measurement · score 0.06

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9Y2T3-F1	alphafold	PREDICTED	97.02	—

Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9Y2T3.

Amino-acid sequence (454 residues)

MCAAQMPPLA HIFRGTFVHS TWTCPMEVLR DHLLGVSDSG KIVFLEEASQ QEKLAKEWCF KPCEIRELSH HEFFMPGLVD THIHASQYSF AGSSIDLPLL EWLTKYTFPA EHRFQNIDFA EEVYTRVVRR TLKNGTTTAC YFATIHTDSS LLLADITDKF GQRAFVGKVC MDLNDTFPEY KETTEESIKE TERFVSEMLQ KNYSRVKPIV TPRFSLSCSE TLMGELGNIA KTRDLHIQSH ISENRDEVEA VKNLYPSYKN YTSVYDKNNL LTNKTVMAHG CYLSAEELNV FHERGASIAH CPNSNLSLSS GFLNVLEVLK HEVKIGLGTD VAGGYSYSML DAIRRAVMVS NILLINKVNE KSLTLKEVFR LATLGGSQAL GLDGEIGNFE VGKEFDAILI NPKASDSPID LFYGDFFGDI SEAVIQKFLY LGDDRNIEEV YVGGKQVVPF SSSV

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards