Guanine deaminase (GDA)
Homo sapiens — UniProt Q9Y2T3
Data last refreshed: (UniProt release unknown)
Key facts
Guanine deaminase (GDA) is a protein from Homo sapiens identified by UniProt accession Q9Y2T3, 454 residues long. MolForge cross-references it against 1 known binders and 97 disease associations.
- UniProt accession: Q9Y2T3; gene symbol GDA.
- Organism: Homo sapiens.
- Length: 454 amino acids.
- Top disease associations (Open Targets): urate measurement, cutaneous melanoma and triple-negative breast cancer.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Guanine deaminase |
|---|---|
| UniProt accession | Q9Y2T3 |
| Gene | GDA |
| Organism | Homo sapiens |
| Length | 454 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (97)
Diseases linked to this target (Open Targets).
- urate measurement · score 0.43
- cutaneous melanoma · score 0.18
- triple-negative breast cancer · score 0.09
- non-small cell lung carcinoma · score 0.08
- adolescent idiopathic scoliosis · score 0.08
- retinopathy · score 0.07
- optic choroid disorder · score 0.07
- psoriasis · score 0.07
- Barrett's esophagus · score 0.06
- serum albumin measurement · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9Y2T3-F1 | alphafold | PREDICTED | 97.02 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9Y2T3.
Amino-acid sequence (454 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with GDA?
The strongest Open Targets associations for GDA are urate measurement, cutaneous melanoma, triple-negative breast cancer, non-small cell lung carcinoma and adolescent idiopathic scoliosis.
How long is the GDA protein?
The Homo sapiens GDA protein (UniProt Q9Y2T3) is 454 amino acids long.
Browse: Targets: G · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9Y2T3 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9Y2T3 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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