Serine/threonine-protein phosphatase 2A 55 kDa…

About Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform

Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform (PPP2R2C) is a protein from Homo sapiens identified by UniProt accession Q9Y2T4, 447 residues long. MolForge cross-references it against 0 known binders and 60 disease associations.

Target properties

Protein name	Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform
UniProt accession	Q9Y2T4
Gene	PPP2R2C
Organism	Homo sapiens
Length	447 residues
Molecular weight	—
EC numbers	—
Target class	—
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (60)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.51
blood protein measurement · score 0.38
type 2 diabetes mellitus · score 0.27
astrocytoma · score 0.06
non-small cell lung carcinoma · score 0.05
glioblastoma multiforme · score 0.04
esophageal adenocarcinoma · score 0.04
pancreatic adenocarcinoma · score 0.03
atypical teratoid rhabdoid tumor · score 0.03
central nervous system cancer · score 0.03

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9Y2T4-F1	alphafold	PREDICTED	89.52	—

Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9Y2T4.

Amino-acid sequence (447 residues)

MGEDTDTRKI NHSFLRDHSY VTEADIISTV EFNHTGELLA TGDKGGRVVI FQREPESKNA PHSQGEYDVY STFQSHEPEF DYLKSLEIEE KINKIKWLPQ QNAAHSLLST NDKTIKLWKI TERDKRPEGY NLKDEEGKLK DLSTVTSLQV PVLKPMDLMV EVSPRRIFAN GHTYHINSIS VNSDCETYMS ADDLRINLWH LAITDRSFNI VDIKPANMED LTEVITASEF HPHHCNLFVY SSSKGSLRLC DMRAAALCDK HSKLFEEPED PSNRSFFSEI ISSVSDVKFS HSGRYMLTRD YLTVKVWDLN MEARPIETYQ VHDYLRSKLC SLYENDCIFD KFECAWNGSD SVIMTGAYNN FFRMFDRNTK RDVTLEASRE SSKPRAVLKP RRVCVGGKRR RDDISVDSLD FTKKILHTAW HPAENIIAIA ATNNLYIFQD KVNSDMH

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards

Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform (PPP2R2C)