Inner nuclear membrane protein Man1 (LEMD3)
Homo sapiens — UniProt Q9Y2U8
Data last refreshed: (UniProt release unknown)
Key facts
Inner nuclear membrane protein Man1 (LEMD3) is a protein from Homo sapiens identified by UniProt accession Q9Y2U8, 911 residues long. MolForge cross-references it against 0 known binders and 78 disease associations.
- UniProt accession: Q9Y2U8; gene symbol LEMD3.
- Organism: Homo sapiens.
- Length: 911 amino acids.
- Top disease associations (Open Targets): Buschke-Ollendorff syndrome, osteopoikilosis and melorheostosis with osteopoikilosis.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Inner nuclear membrane protein Man1 |
|---|---|
| UniProt accession | Q9Y2U8 |
| Gene | LEMD3 |
| Organism | Homo sapiens |
| Length | 911 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (78)
Diseases linked to this target (Open Targets).
- Buschke-Ollendorff syndrome · score 0.78
- osteopoikilosis · score 0.51
- melorheostosis with osteopoikilosis · score 0.51
- melorheostosis · score 0.47
- isolated osteopoikilosis · score 0.37
- Cerebral arteriovenous malformation · score 0.34
- genetic disorder · score 0.19
- gut microbiome measurement · score 0.14
- fat body mass · score 0.13
- lean body mass · score 0.13
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9Y2U8-F1 | alphafold | PREDICTED | 59.64 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9Y2U8.
Amino-acid sequence (911 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with LEMD3?
The strongest Open Targets associations for LEMD3 are Buschke-Ollendorff syndrome, osteopoikilosis, melorheostosis with osteopoikilosis, melorheostosis and isolated osteopoikilosis.
How long is the LEMD3 protein?
The Homo sapiens LEMD3 protein (UniProt Q9Y2U8) is 911 amino acids long.
Browse: Targets: L · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9Y2U8 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9Y2U8 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.