Kelch domain-containing protein 2 (KLHDC2)
Homo sapiens — UniProt Q9Y2U9
Data last refreshed: (UniProt release unknown)
Key facts
Kelch domain-containing protein 2 (KLHDC2) is a protein from Homo sapiens identified by UniProt accession Q9Y2U9, 406 residues long. MolForge cross-references it against 0 known binders and 128 disease associations.
- UniProt accession: Q9Y2U9; gene symbol KLHDC2.
- Organism: Homo sapiens.
- Length: 406 amino acids.
- Top disease associations (Open Targets): intellectual developmental disorder with speech delay and axonal peripheral neuropathy, genetic disorder and metabolite measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Kelch domain-containing protein 2 |
|---|---|
| UniProt accession | Q9Y2U9 |
| Gene | KLHDC2 |
| Organism | Homo sapiens |
| Length | 406 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (128)
Diseases linked to this target (Open Targets).
- intellectual developmental disorder with speech delay and axonal peripheral neuropathy · score 0.27
- genetic disorder · score 0.18
- metabolite measurement · score 0.10
- Young adult-onset Parkinsonism · score 0.07
- essential tremor · score 0.07
- Hereditary late-onset Parkinson disease · score 0.07
- X-linked parkinsonism-spasticity syndrome · score 0.06
- Fuchs endothelial corneal dystrophy · score 0.06
- corneal-cerebellar syndrome · score 0.06
- spinocerebellar ataxia type 15/16 · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9Y2U9-F1 | alphafold | PREDICTED | 89.68 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9Y2U9.
Amino-acid sequence (406 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with KLHDC2?
The strongest Open Targets associations for KLHDC2 are intellectual developmental disorder with speech delay and axonal peripheral neuropathy, genetic disorder, metabolite measurement, Young adult-onset Parkinsonism and essential tremor.
How long is the KLHDC2 protein?
The Homo sapiens KLHDC2 protein (UniProt Q9Y2U9) is 406 amino acids long.
Browse: Targets: K · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9Y2U9 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9Y2U9 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.