Conserved oligomeric Golgi complex subunit 6 (COG6)
Homo sapiens — UniProt Q9Y2V7
Data last refreshed: (UniProt release unknown)
Key facts
Conserved oligomeric Golgi complex subunit 6 (COG6) is a protein from Homo sapiens identified by UniProt accession Q9Y2V7, 657 residues long. MolForge cross-references it against 0 known binders and 380 disease associations.
- UniProt accession: Q9Y2V7; gene symbol COG6.
- Organism: Homo sapiens.
- Length: 657 amino acids.
- Top disease associations (Open Targets): COG6-ongenital disorder of glycosylation, hypohidrosis-enamel hypoplasia-palmoplantar keratoderma-intellectual disability syndrome and congenital disorder of glycosylation.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Conserved oligomeric Golgi complex subunit 6 |
|---|---|
| UniProt accession | Q9Y2V7 |
| Gene | COG6 |
| Organism | Homo sapiens |
| Length | 657 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (380)
Diseases linked to this target (Open Targets).
- COG6-ongenital disorder of glycosylation · score 0.76
- hypohidrosis-enamel hypoplasia-palmoplantar keratoderma-intellectual disability syndrome · score 0.75
- congenital disorder of glycosylation · score 0.56
- neurodegenerative disease · score 0.55
- genetic disorder · score 0.45
- eosinophil count · score 0.43
- rheumatoid arthritis · score 0.40
- eosinophil percentage of leukocytes · score 0.38
- body height · score 0.37
- asthma · score 0.35
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9Y2V7-F1 | alphafold | PREDICTED | 85.95 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9Y2V7.
Amino-acid sequence (657 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with COG6?
The strongest Open Targets associations for COG6 are COG6-ongenital disorder of glycosylation, hypohidrosis-enamel hypoplasia-palmoplantar keratoderma-intellectual disability syndrome, congenital disorder of glycosylation, neurodegenerative disease and genetic disorder.
How long is the COG6 protein?
The Homo sapiens COG6 protein (UniProt Q9Y2V7) is 657 amino acids long.
Browse: Targets: C · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9Y2V7 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9Y2V7 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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