Thyroid hormone receptor-associated protein 3 (THRAP3)
Homo sapiens — UniProt Q9Y2W1
Data last refreshed: (UniProt release unknown)
Key facts
Thyroid hormone receptor-associated protein 3 (THRAP3) is a protein from Homo sapiens identified by UniProt accession Q9Y2W1, 955 residues long. MolForge cross-references it against 0 known binders and 137 disease associations.
- UniProt accession: Q9Y2W1; gene symbol THRAP3.
- Organism: Homo sapiens.
- Length: 955 amino acids.
- Top disease associations (Open Targets): reticulocyte measurement, reticulocyte count and lung adenocarcinoma.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Thyroid hormone receptor-associated protein 3 |
|---|---|
| UniProt accession | Q9Y2W1 |
| Gene | THRAP3 |
| Organism | Homo sapiens |
| Length | 955 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (137)
Diseases linked to this target (Open Targets).
- reticulocyte measurement · score 0.22
- reticulocyte count · score 0.20
- lung adenocarcinoma · score 0.19
- urinary bladder carcinoma · score 0.19
- chronic lymphocytic leukemia · score 0.19
- hepatocellular carcinoma · score 0.19
- melanoma · score 0.19
- acute myeloid leukemia · score 0.19
- head and neck squamous cell carcinoma · score 0.19
- kidney neoplasm · score 0.19
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9Y2W1-F1 | alphafold | PREDICTED | 45.93 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9Y2W1.
Amino-acid sequence (955 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with THRAP3?
The strongest Open Targets associations for THRAP3 are reticulocyte measurement, reticulocyte count, lung adenocarcinoma, urinary bladder carcinoma and chronic lymphocytic leukemia.
How long is the THRAP3 protein?
The Homo sapiens THRAP3 protein (UniProt Q9Y2W1) is 955 amino acids long.
Browse: Targets: T · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9Y2W1 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9Y2W1 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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