Proton-associated sugar transporter A (SLC45A1)
Homo sapiens — UniProt Q9Y2W3
Data last refreshed: (UniProt release unknown)
Key facts
Proton-associated sugar transporter A (SLC45A1) is a protein from Homo sapiens identified by UniProt accession Q9Y2W3, 748 residues long. MolForge cross-references it against 0 known binders and 108 disease associations.
- UniProt accession: Q9Y2W3; gene symbol SLC45A1.
- Organism: Homo sapiens.
- Length: 748 amino acids.
- Target class: Transporter.
- Top disease associations (Open Targets): intellectual developmental disorder with neuropsychiatric features, autosomal recessive non-syndromic intellectual disability and protein measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Proton-associated sugar transporter A |
|---|---|
| UniProt accession | Q9Y2W3 |
| Gene | SLC45A1 |
| Organism | Homo sapiens |
| Length | 748 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | Transporter (inferred from UniProt keywords / EC) |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (108)
Diseases linked to this target (Open Targets).
- intellectual developmental disorder with neuropsychiatric features · score 0.65
- autosomal recessive non-syndromic intellectual disability · score 0.37
- protein measurement · score 0.36
- hair colour measurement · score 0.34
- psoriasis · score 0.33
- appendicular lean mass · score 0.33
- hair color · score 0.33
- reticulocyte measurement · score 0.32
- reticulocyte count · score 0.29
- skin aging measurement · score 0.27
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9Y2W3-F1 | alphafold | PREDICTED | 65.88 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9Y2W3.
Amino-acid sequence (748 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SLC45A1?
The strongest Open Targets associations for SLC45A1 are intellectual developmental disorder with neuropsychiatric features, autosomal recessive non-syndromic intellectual disability, protein measurement, hair colour measurement and psoriasis.
How long is the SLC45A1 protein?
The Homo sapiens SLC45A1 protein (UniProt Q9Y2W3) is 748 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9Y2W3 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9Y2W3 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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