Tudor and KH domain-containing protein (TDRKH)
Homo sapiens — UniProt Q9Y2W6
Data last refreshed: (UniProt release unknown)
Key facts
Tudor and KH domain-containing protein (TDRKH) is a protein from Homo sapiens identified by UniProt accession Q9Y2W6, 561 residues long. MolForge cross-references it against 0 known binders and 115 disease associations.
- UniProt accession: Q9Y2W6; gene symbol TDRKH.
- Organism: Homo sapiens.
- Length: 561 amino acids.
- Top disease associations (Open Targets): azoospermia, distal hereditary motor neuropathy and coronary artery disease.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Tudor and KH domain-containing protein |
|---|---|
| UniProt accession | Q9Y2W6 |
| Gene | TDRKH |
| Organism | Homo sapiens |
| Length | 561 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (115)
Diseases linked to this target (Open Targets).
- azoospermia · score 0.35
- distal hereditary motor neuropathy · score 0.26
- coronary artery disease · score 0.24
- hemoglobin measurement · score 0.21
- hematocrit · score 0.20
- serum gamma-glutamyl transferase measurement · score 0.17
- myocardial infarction · score 0.16
- attention deficit hyperactivity disorder · score 0.16
- substance abuse · score 0.16
- antisocial behaviour measurement · score 0.16
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9Y2W6-F1 | alphafold | PREDICTED | 74.35 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9Y2W6.
Amino-acid sequence (561 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with TDRKH?
The strongest Open Targets associations for TDRKH are azoospermia, distal hereditary motor neuropathy, coronary artery disease, hemoglobin measurement and hematocrit.
How long is the TDRKH protein?
The Homo sapiens TDRKH protein (UniProt Q9Y2W6) is 561 amino acids long.
Browse: Targets: T · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9Y2W6 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9Y2W6 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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