Calsenilin (KCNIP3)
Homo sapiens — UniProt Q9Y2W7
Data last refreshed: (UniProt release unknown)
Key facts
Calsenilin (KCNIP3) is a protein from Homo sapiens identified by UniProt accession Q9Y2W7, 256 residues long. MolForge cross-references it against 0 known binders and 144 disease associations.
- UniProt accession: Q9Y2W7; gene symbol KCNIP3.
- Organism: Homo sapiens.
- Length: 256 amino acids.
- Top disease associations (Open Targets): Parkinson disease, cutaneous melanoma and systemic scleroderma.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Calsenilin |
|---|---|
| UniProt accession | Q9Y2W7 |
| Gene | KCNIP3 |
| Organism | Homo sapiens |
| Length | 256 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (144)
Diseases linked to this target (Open Targets).
- Parkinson disease · score 0.27
- cutaneous melanoma · score 0.14
- systemic scleroderma · score 0.07
- Huntington disease · score 0.07
- cancer · score 0.07
- Gollop-Wolfgang complex · score 0.06
- serum urea measurement · score 0.06
- tibial hemimelia · score 0.06
- tibia, hypoplasia or aplasia of, with polydactyly · score 0.06
- fibular aplasia-ectrodactyly syndrome · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9Y2W7-F1 | alphafold | PREDICTED | 69.01 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9Y2W7.
Amino-acid sequence (256 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with KCNIP3?
The strongest Open Targets associations for KCNIP3 are Parkinson disease, cutaneous melanoma, systemic scleroderma, Huntington disease and cancer.
How long is the KCNIP3 protein?
The Homo sapiens KCNIP3 protein (UniProt Q9Y2W7) is 256 amino acids long.
Browse: Targets: K · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9Y2W7 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9Y2W7 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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