Mediator of RNA polymerase II transcription subunit 16 (MED16)
Homo sapiens — UniProt Q9Y2X0
Data last refreshed: (UniProt release unknown)
Key facts
Mediator of RNA polymerase II transcription subunit 16 (MED16) is a protein from Homo sapiens identified by UniProt accession Q9Y2X0, 877 residues long. MolForge cross-references it against 0 known binders and 26 disease associations.
- UniProt accession: Q9Y2X0; gene symbol MED16.
- Organism: Homo sapiens.
- Length: 877 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, reticulocyte count and Immature Reticulocyte Fraction Measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Mediator of RNA polymerase II transcription subunit 16 |
|---|---|
| UniProt accession | Q9Y2X0 |
| Gene | MED16 |
| Organism | Homo sapiens |
| Length | 877 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (26)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.49
- reticulocyte count · score 0.25
- Immature Reticulocyte Fraction Measurement · score 0.23
- reticulocyte measurement · score 0.20
- blood protein measurement · score 0.17
- melanoma · score 0.15
- oral cavity carcinoma · score 0.15
- neurofibrillary tangles measurement · score 0.12
- breast adenocarcinoma · score 0.11
- breast cancer · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9Y2X0-F1 | alphafold | PREDICTED | 83.97 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9Y2X0.
Amino-acid sequence (877 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with MED16?
The strongest Open Targets associations for MED16 are neurodegenerative disease, reticulocyte count, Immature Reticulocyte Fraction Measurement, reticulocyte measurement and blood protein measurement.
How long is the MED16 protein?
The Homo sapiens MED16 protein (UniProt Q9Y2X0) is 877 amino acids long.
Browse: Targets: M · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9Y2X0 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9Y2X0 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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