Nucleolar protein 58 (NOP58)
Homo sapiens — UniProt Q9Y2X3
Data last refreshed: (UniProt release unknown)
Key facts
Nucleolar protein 58 (NOP58) is a protein from Homo sapiens identified by UniProt accession Q9Y2X3, 529 residues long. MolForge cross-references it against 0 known binders and 47 disease associations.
- UniProt accession: Q9Y2X3; gene symbol NOP58.
- Organism: Homo sapiens.
- Length: 529 amino acids.
- Top disease associations (Open Targets): pulmonary hypertension, primary, 1, total cholesterol measurement and low density lipoprotein cholesterol measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Nucleolar protein 58 |
|---|---|
| UniProt accession | Q9Y2X3 |
| Gene | NOP58 |
| Organism | Homo sapiens |
| Length | 529 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (47)
Diseases linked to this target (Open Targets).
- pulmonary hypertension, primary, 1 · score 0.33
- total cholesterol measurement · score 0.29
- low density lipoprotein cholesterol measurement · score 0.28
- apolipoprotein B measurement · score 0.28
- body height · score 0.27
- C-reactive protein measurement · score 0.25
- IGF-1 measurement · score 0.25
- endometrial cancer · score 0.24
- breast adenocarcinoma · score 0.23
- mean corpuscular hemoglobin concentration · score 0.19
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9Y2X3-F1 | alphafold | PREDICTED | 75.68 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9Y2X3.
Amino-acid sequence (529 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with NOP58?
The strongest Open Targets associations for NOP58 are pulmonary hypertension, primary, 1, total cholesterol measurement, low density lipoprotein cholesterol measurement, apolipoprotein B measurement and body height.
How long is the NOP58 protein?
The Homo sapiens NOP58 protein (UniProt Q9Y2X3) is 529 amino acids long.
Browse: Targets: N · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9Y2X3 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9Y2X3 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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