ARF GTPase-activating protein GIT1 (GIT1)
Homo sapiens — UniProt Q9Y2X7
Data last refreshed: (UniProt release unknown)
Key facts
ARF GTPase-activating protein GIT1 (GIT1) is a protein from Homo sapiens identified by UniProt accession Q9Y2X7, 761 residues long. MolForge cross-references it against 0 known binders and 129 disease associations.
- UniProt accession: Q9Y2X7; gene symbol GIT1.
- Organism: Homo sapiens.
- Length: 761 amino acids.
- Top disease associations (Open Targets): body height, neurodegenerative disease and fat body mass.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | ARF GTPase-activating protein GIT1 |
|---|---|
| UniProt accession | Q9Y2X7 |
| Gene | GIT1 |
| Organism | Homo sapiens |
| Length | 761 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (129)
Diseases linked to this target (Open Targets).
- body height · score 0.33
- neurodegenerative disease · score 0.32
- fat body mass · score 0.28
- genetic disorder · score 0.19
- head and neck squamous cell carcinoma · score 0.13
- neoplasm · score 0.11
- hepatocellular carcinoma · score 0.10
- non-small cell lung carcinoma · score 0.09
- lymphocyte count · score 0.09
- coronary artery disease · score 0.09
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9Y2X7-F1 | alphafold | PREDICTED | 74.20 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9Y2X7.
Amino-acid sequence (761 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with GIT1?
The strongest Open Targets associations for GIT1 are body height, neurodegenerative disease, fat body mass, genetic disorder and head and neck squamous cell carcinoma.
How long is the GIT1 protein?
The Homo sapiens GIT1 protein (UniProt Q9Y2X7) is 761 amino acids long.
Browse: Targets: G · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9Y2X7 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9Y2X7 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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