Zinc finger protein 281 (ZNF281)
Homo sapiens — UniProt Q9Y2X9
Data last refreshed: (UniProt release unknown)
Key facts
Zinc finger protein 281 (ZNF281) is a protein from Homo sapiens identified by UniProt accession Q9Y2X9, 895 residues long. MolForge cross-references it against 0 known binders and 98 disease associations.
- UniProt accession: Q9Y2X9; gene symbol ZNF281.
- Organism: Homo sapiens.
- Length: 895 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, sex hormone-binding globulin measurement and neutrophil count.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Zinc finger protein 281 |
|---|---|
| UniProt accession | Q9Y2X9 |
| Gene | ZNF281 |
| Organism | Homo sapiens |
| Length | 895 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (98)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.56
- sex hormone-binding globulin measurement · score 0.29
- neutrophil count · score 0.28
- urate measurement · score 0.26
- calcium measurement · score 0.26
- serum gamma-glutamyl transferase measurement · score 0.25
- myeloid white cell count · score 0.22
- Myopia · score 0.21
- eosinophil percentage of leukocytes · score 0.21
- refractive error measurement · score 0.21
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9Y2X9-F1 | alphafold | PREDICTED | 46.54 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9Y2X9.
Amino-acid sequence (895 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with ZNF281?
The strongest Open Targets associations for ZNF281 are neurodegenerative disease, sex hormone-binding globulin measurement, neutrophil count, urate measurement and calcium measurement.
How long is the ZNF281 protein?
The Homo sapiens ZNF281 protein (UniProt Q9Y2X9) is 895 amino acids long.
Browse: Targets: Z · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9Y2X9 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9Y2X9 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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