ADP-ribosylation factor-like protein 2-binding protein (ARL2BP)
Homo sapiens — UniProt Q9Y2Y0
Data last refreshed: (UniProt release unknown)
Key facts
ADP-ribosylation factor-like protein 2-binding protein (ARL2BP) is a protein from Homo sapiens identified by UniProt accession Q9Y2Y0, 163 residues long. MolForge cross-references it against 0 known binders and 140 disease associations.
- UniProt accession: Q9Y2Y0; gene symbol ARL2BP.
- Organism: Homo sapiens.
- Length: 163 amino acids.
- Top disease associations (Open Targets): retinitis pigmentosa, Retinal dystrophy and autosomal recessive retinitis pigmentosa.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | ADP-ribosylation factor-like protein 2-binding protein |
|---|---|
| UniProt accession | Q9Y2Y0 |
| Gene | ARL2BP |
| Organism | Homo sapiens |
| Length | 163 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (140)
Diseases linked to this target (Open Targets).
- retinitis pigmentosa · score 0.67
- Retinal dystrophy · score 0.43
- autosomal recessive retinitis pigmentosa · score 0.42
- genetic disorder · score 0.18
- mean corpuscular hemoglobin concentration · score 0.09
- azoospermia · score 0.08
- neoplasm · score 0.08
- male infertility with teratozoospermia due to single gene mutation · score 0.07
- partial chromosome Y deletion · score 0.06
- spermatogenic failure 65 · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9Y2Y0-F1 | alphafold | PREDICTED | 80.81 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9Y2Y0.
Amino-acid sequence (163 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with ARL2BP?
The strongest Open Targets associations for ARL2BP are retinitis pigmentosa, Retinal dystrophy, autosomal recessive retinitis pigmentosa, genetic disorder and mean corpuscular hemoglobin concentration.
How long is the ARL2BP protein?
The Homo sapiens ARL2BP protein (UniProt Q9Y2Y0) is 163 amino acids long.
Browse: Targets: A · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9Y2Y0 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9Y2Y0 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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