DNA-directed RNA polymerase III subunit RPC10 (POLR3K)
Homo sapiens — UniProt Q9Y2Y1
Data last refreshed: (UniProt release unknown)
Key facts
DNA-directed RNA polymerase III subunit RPC10 (POLR3K) is a protein from Homo sapiens identified by UniProt accession Q9Y2Y1, 108 residues long. MolForge cross-references it against 0 known binders and 17 disease associations.
- UniProt accession: Q9Y2Y1; gene symbol POLR3K.
- Organism: Homo sapiens.
- Length: 108 amino acids.
- Top disease associations (Open Targets): mean corpuscular volume, mean corpuscular hemoglobin and mean corpuscular hemoglobin concentration.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | DNA-directed RNA polymerase III subunit RPC10 |
|---|---|
| UniProt accession | Q9Y2Y1 |
| Gene | POLR3K |
| Organism | Homo sapiens |
| Length | 108 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (17)
Diseases linked to this target (Open Targets).
- mean corpuscular volume · score 0.19
- mean corpuscular hemoglobin · score 0.19
- mean corpuscular hemoglobin concentration · score 0.12
- erythrocyte count · score 0.09
- HbA1c measurement · score 0.03
- leukodystrophy · score 0.01
- breast carcinoma · score 0.01
- Miyoshi myopathy · score 0.00
- systemic scleroderma · score 0.00
- Alzheimer disease · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9Y2Y1-F1 | alphafold | PREDICTED | 84.85 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9Y2Y1.
Amino-acid sequence (108 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with POLR3K?
The strongest Open Targets associations for POLR3K are mean corpuscular volume, mean corpuscular hemoglobin, mean corpuscular hemoglobin concentration, erythrocyte count and HbA1c measurement.
How long is the POLR3K protein?
The Homo sapiens POLR3K protein (UniProt Q9Y2Y1) is 108 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9Y2Y1 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9Y2Y1 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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