Proteoglycan 3 (PRG3)
Homo sapiens — UniProt Q9Y2Y8
Data last refreshed: (UniProt release unknown)
Key facts
Proteoglycan 3 (PRG3) is a protein from Homo sapiens identified by UniProt accession Q9Y2Y8, 225 residues long. MolForge cross-references it against 0 known binders and 19 disease associations.
- UniProt accession: Q9Y2Y8; gene symbol PRG3.
- Organism: Homo sapiens.
- Length: 225 amino acids.
- Top disease associations (Open Targets): eosinophil count, eosinophil percentage of leukocytes and hypertrophic cardiomyopathy.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Proteoglycan 3 |
|---|---|
| UniProt accession | Q9Y2Y8 |
| Gene | PRG3 |
| Organism | Homo sapiens |
| Length | 225 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (19)
Diseases linked to this target (Open Targets).
- eosinophil count · score 0.46
- eosinophil percentage of leukocytes · score 0.40
- hypertrophic cardiomyopathy · score 0.12
- osteosarcoma · score 0.05
- mean corpuscular hemoglobin concentration · score 0.04
- smoking behaviour measurement · score 0.03
- unipolar depression · score 0.03
- dilated cardiomyopathy 1I · score 0.03
- DNA methylation · score 0.02
- monocyte percentage of leukocytes · score 0.02
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9Y2Y8-F1 | alphafold | PREDICTED | 76.67 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9Y2Y8.
Amino-acid sequence (225 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with PRG3?
The strongest Open Targets associations for PRG3 are eosinophil count, eosinophil percentage of leukocytes, hypertrophic cardiomyopathy, osteosarcoma and mean corpuscular hemoglobin concentration.
How long is the PRG3 protein?
The Homo sapiens PRG3 protein (UniProt Q9Y2Y8) is 225 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9Y2Y8 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9Y2Y8 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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