Tyrosine--tRNA ligase, mitochondrial (YARS2)
Homo sapiens — UniProt Q9Y2Z4
Data last refreshed: (UniProt release unknown)
Key facts
Tyrosine--tRNA ligase, mitochondrial (YARS2) is a protein from Homo sapiens identified by UniProt accession Q9Y2Z4, 477 residues long. MolForge cross-references it against 0 known binders and 51 disease associations.
- UniProt accession: Q9Y2Z4; gene symbol YARS2.
- Organism: Homo sapiens.
- Length: 477 amino acids.
- Top disease associations (Open Targets): Mitochondrial myopathy and sideroblastic anemia, neurodegenerative disease and mitochondrial disease.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Tyrosine--tRNA ligase, mitochondrial |
|---|---|
| UniProt accession | Q9Y2Z4 |
| Gene | YARS2 |
| Organism | Homo sapiens |
| Length | 477 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (51)
Diseases linked to this target (Open Targets).
- Mitochondrial myopathy and sideroblastic anemia · score 0.80
- neurodegenerative disease · score 0.48
- mitochondrial disease · score 0.42
- mean platelet volume · score 0.33
- platelet count · score 0.31
- platelet component distribution width · score 0.19
- genetic disorder · score 0.19
- myopathy, lactic acidosis, and sideroblastic anemia · score 0.19
- atrial fibrillation · score 0.12
- blood protein measurement · score 0.11
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9Y2Z4-F1 | alphafold | PREDICTED | 87.17 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9Y2Z4.
Amino-acid sequence (477 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with YARS2?
The strongest Open Targets associations for YARS2 are Mitochondrial myopathy and sideroblastic anemia, neurodegenerative disease, mitochondrial disease, mean platelet volume and platelet count.
How long is the YARS2 protein?
The Homo sapiens YARS2 protein (UniProt Q9Y2Z4) is 477 amino acids long.
Browse: Targets: Y · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9Y2Z4 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9Y2Z4 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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