Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial (COQ6)
Homo sapiens — UniProt Q9Y2Z9
Data last refreshed: (UniProt release unknown)
Key facts
Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial (COQ6) is a protein from Homo sapiens identified by UniProt accession Q9Y2Z9, 468 residues long. MolForge cross-references it against 0 known binders and 66 disease associations.
- UniProt accession: Q9Y2Z9; gene symbol COQ6.
- Organism: Homo sapiens.
- Length: 468 amino acids.
- Top disease associations (Open Targets): familial steroid-resistant nephrotic syndrome with sensorineural deafness, neurodegenerative disease and steroid-resistant nephrotic syndrome.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial |
|---|---|
| UniProt accession | Q9Y2Z9 |
| Gene | COQ6 |
| Organism | Homo sapiens |
| Length | 468 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (66)
Diseases linked to this target (Open Targets).
- familial steroid-resistant nephrotic syndrome with sensorineural deafness · score 0.80
- neurodegenerative disease · score 0.56
- steroid-resistant nephrotic syndrome · score 0.50
- lysosomal storage disease · score 0.25
- genetic disorder · score 0.19
- mean corpuscular volume · score 0.14
- Red cell distribution width · score 0.06
- aspartate aminotransferase measurement · score 0.05
- protein measurement · score 0.05
- blood protein measurement · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9Y2Z9-F1 | alphafold | PREDICTED | 83.96 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9Y2Z9.
Amino-acid sequence (468 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with COQ6?
The strongest Open Targets associations for COQ6 are familial steroid-resistant nephrotic syndrome with sensorineural deafness, neurodegenerative disease, steroid-resistant nephrotic syndrome, lysosomal storage disease and genetic disorder.
How long is the COQ6 protein?
The Homo sapiens COQ6 protein (UniProt Q9Y2Z9) is 468 amino acids long.
Browse: Targets: C · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9Y2Z9 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9Y2Z9 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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