Endophilin-B1 (SH3GLB1)
Homo sapiens — UniProt Q9Y371
Data last refreshed: (UniProt release unknown)
Key facts
Endophilin-B1 (SH3GLB1) is a protein from Homo sapiens identified by UniProt accession Q9Y371, 365 residues long. MolForge cross-references it against 0 known binders and 46 disease associations.
- UniProt accession: Q9Y371; gene symbol SH3GLB1.
- Organism: Homo sapiens.
- Length: 365 amino acids.
- Top disease associations (Open Targets): neoplasm, glioblastoma multiforme and ovarian carcinoma.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Endophilin-B1 |
|---|---|
| UniProt accession | Q9Y371 |
| Gene | SH3GLB1 |
| Organism | Homo sapiens |
| Length | 365 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (46)
Diseases linked to this target (Open Targets).
- neoplasm · score 0.03
- glioblastoma multiforme · score 0.02
- ovarian carcinoma · score 0.02
- Sepsis · score 0.02
- cancer · score 0.01
- mucocutaneous lymph node syndrome · score 0.01
- bacteriemia · score 0.01
- benign prostatic hyperplasia · score 0.01
- colorectal adenocarcinoma · score 0.01
- cardiac hypertrophy · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9Y371-F1 | alphafold | PREDICTED | 83.88 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9Y371.
Amino-acid sequence (365 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SH3GLB1?
The strongest Open Targets associations for SH3GLB1 are neoplasm, glioblastoma multiforme, ovarian carcinoma, Sepsis and cancer.
How long is the SH3GLB1 protein?
The Homo sapiens SH3GLB1 protein (UniProt Q9Y371) is 365 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9Y371 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9Y371 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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