Ubiquinone biosynthesis protein COQ4 homolog, mitochondrial (COQ4)
Homo sapiens — UniProt Q9Y3A0
Data last refreshed: (UniProt release unknown)
Key facts
Ubiquinone biosynthesis protein COQ4 homolog, mitochondrial (COQ4) is a protein from Homo sapiens identified by UniProt accession Q9Y3A0, 265 residues long. MolForge cross-references it against 0 known binders and 41 disease associations.
- UniProt accession: Q9Y3A0; gene symbol COQ4.
- Organism: Homo sapiens.
- Length: 265 amino acids.
- Top disease associations (Open Targets): neonatal encephalomyopathy-cardiomyopathy-respiratory distress syndrome, coenzyme Q10 deficiency and neurodegenerative disease.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Ubiquinone biosynthesis protein COQ4 homolog, mitochondrial |
|---|---|
| UniProt accession | Q9Y3A0 |
| Gene | COQ4 |
| Organism | Homo sapiens |
| Length | 265 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (41)
Diseases linked to this target (Open Targets).
- neonatal encephalomyopathy-cardiomyopathy-respiratory distress syndrome · score 0.83
- coenzyme Q10 deficiency · score 0.57
- neurodegenerative disease · score 0.52
- spastic ataxia · score 0.48
- genetic disorder · score 0.47
- mitochondrial disease · score 0.37
- rhabdomyolysis · score 0.37
- Abnormality of the nervous system · score 0.27
- PHF-tau measurement · score 0.24
- high density lipoprotein cholesterol measurement · score 0.12
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9Y3A0-F1 | alphafold | PREDICTED | 88.14 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9Y3A0.
Amino-acid sequence (265 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with COQ4?
The strongest Open Targets associations for COQ4 are neonatal encephalomyopathy-cardiomyopathy-respiratory distress syndrome, coenzyme Q10 deficiency, neurodegenerative disease, spastic ataxia and genetic disorder.
How long is the COQ4 protein?
The Homo sapiens COQ4 protein (UniProt Q9Y3A0) is 265 amino acids long.
Browse: Targets: C · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9Y3A0 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9Y3A0 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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