Ribosome maturation protein SBDS (SBDS)
Homo sapiens — UniProt Q9Y3A5
Data last refreshed: (UniProt release unknown)
Key facts
Ribosome maturation protein SBDS (SBDS) is a protein from Homo sapiens identified by UniProt accession Q9Y3A5, 250 residues long. MolForge cross-references it against 0 known binders and 145 disease associations.
- UniProt accession: Q9Y3A5; gene symbol SBDS.
- Organism: Homo sapiens.
- Length: 250 amino acids.
- Top disease associations (Open Targets): Shwachman-Diamond syndrome, Aplastic anemia and acute myeloid leukemia.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Ribosome maturation protein SBDS |
|---|---|
| UniProt accession | Q9Y3A5 |
| Gene | SBDS |
| Organism | Homo sapiens |
| Length | 250 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (145)
Diseases linked to this target (Open Targets).
- Shwachman-Diamond syndrome · score 0.81
- Aplastic anemia · score 0.56
- acute myeloid leukemia · score 0.53
- genetic disorder · score 0.53
- myelodysplastic syndrome · score 0.46
- Microcephaly · score 0.41
- Deeply set eye · score 0.41
- Splenomegaly · score 0.41
- Short stature · score 0.41
- anodontia · score 0.41
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9Y3A5-F1 | alphafold | PREDICTED | 74.07 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9Y3A5.
Amino-acid sequence (250 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SBDS?
The strongest Open Targets associations for SBDS are Shwachman-Diamond syndrome, Aplastic anemia, acute myeloid leukemia, genetic disorder and myelodysplastic syndrome.
How long is the SBDS protein?
The Homo sapiens SBDS protein (UniProt Q9Y3A5) is 250 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9Y3A5 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9Y3A5 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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