Transmembrane emp24 domain-containing protein 5 (TMED5)
Homo sapiens — UniProt Q9Y3A6
Data last refreshed: (UniProt release unknown)
Key facts
Transmembrane emp24 domain-containing protein 5 (TMED5) is a protein from Homo sapiens identified by UniProt accession Q9Y3A6, 229 residues long. MolForge cross-references it against 0 known binders and 58 disease associations.
- UniProt accession: Q9Y3A6; gene symbol TMED5.
- Organism: Homo sapiens.
- Length: 229 amino acids.
- Top disease associations (Open Targets): IGF-1 measurement, self reported educational attainment and high density lipoprotein cholesterol measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Transmembrane emp24 domain-containing protein 5 |
|---|---|
| UniProt accession | Q9Y3A6 |
| Gene | TMED5 |
| Organism | Homo sapiens |
| Length | 229 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (58)
Diseases linked to this target (Open Targets).
- IGF-1 measurement · score 0.22
- self reported educational attainment · score 0.21
- high density lipoprotein cholesterol measurement · score 0.19
- alkaline phosphatase measurement · score 0.17
- erythrocyte count · score 0.16
- eosinophil percentage of leukocytes · score 0.16
- triglyceride measurement · score 0.16
- urate measurement · score 0.15
- neutrophil percentage of granulocytes · score 0.15
- eosinophil percentage of granulocytes · score 0.15
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9Y3A6-F1 | alphafold | PREDICTED | 82.48 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9Y3A6.
Amino-acid sequence (229 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with TMED5?
The strongest Open Targets associations for TMED5 are IGF-1 measurement, self reported educational attainment, high density lipoprotein cholesterol measurement, alkaline phosphatase measurement and erythrocyte count.
How long is the TMED5 protein?
The Homo sapiens TMED5 protein (UniProt Q9Y3A6) is 229 amino acids long.
Browse: Targets: T · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9Y3A6 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9Y3A6 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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