Splicing factor 3B subunit 6 (SF3B6)
Homo sapiens — UniProt Q9Y3B4
Data last refreshed: (UniProt release unknown)
Key facts
Splicing factor 3B subunit 6 (SF3B6) is a protein from Homo sapiens identified by UniProt accession Q9Y3B4, 125 residues long. MolForge cross-references it against 0 known binders and 24 disease associations.
- UniProt accession: Q9Y3B4; gene symbol SF3B6.
- Organism: Homo sapiens.
- Length: 125 amino acids.
- Top disease associations (Open Targets): reticulocyte count, reticulocyte measurement and lifestyle measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Splicing factor 3B subunit 6 |
|---|---|
| UniProt accession | Q9Y3B4 |
| Gene | SF3B6 |
| Organism | Homo sapiens |
| Length | 125 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (24)
Diseases linked to this target (Open Targets).
- reticulocyte count · score 0.11
- reticulocyte measurement · score 0.09
- lifestyle measurement · score 0.05
- sum of neutrophil and eosinophil counts · score 0.05
- myeloid white cell count · score 0.05
- granulocyte count · score 0.05
- neutrophil count · score 0.04
- platelet component distribution width · score 0.04
- sum of basophil and neutrophil counts · score 0.04
- metabolite measurement · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9Y3B4-F1 | alphafold | PREDICTED | 90.12 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9Y3B4.
Amino-acid sequence (125 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SF3B6?
The strongest Open Targets associations for SF3B6 are reticulocyte count, reticulocyte measurement, lifestyle measurement, sum of neutrophil and eosinophil counts and myeloid white cell count.
How long is the SF3B6 protein?
The Homo sapiens SF3B6 protein (UniProt Q9Y3B4) is 125 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9Y3B4 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9Y3B4 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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