Oligoribonuclease, mitochondrial (REXO2)
Homo sapiens — UniProt Q9Y3B8
Data last refreshed: (UniProt release unknown)
Key facts
Oligoribonuclease, mitochondrial (REXO2) is a protein from Homo sapiens identified by UniProt accession Q9Y3B8, 237 residues long. MolForge cross-references it against 0 known binders and 57 disease associations.
- UniProt accession: Q9Y3B8; gene symbol REXO2.
- Organism: Homo sapiens.
- Length: 237 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, ulcerative colitis and lysosomal storage disease.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Oligoribonuclease, mitochondrial |
|---|---|
| UniProt accession | Q9Y3B8 |
| Gene | REXO2 |
| Organism | Homo sapiens |
| Length | 237 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (57)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.51
- ulcerative colitis · score 0.30
- lysosomal storage disease · score 0.26
- blood protein measurement · score 0.12
- Combined hyperlipidemia · score 0.04
- cholesterol-ester transfer protein deficiency · score 0.04
- hypertriglyceridemia 2 · score 0.04
- glycogen storage disease VI · score 0.04
- familial apolipoprotein C-II deficiency · score 0.03
- Hyperlipoproteinemia type 1 · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9Y3B8-F1 | alphafold | PREDICTED | 88.17 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9Y3B8.
Amino-acid sequence (237 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with REXO2?
The strongest Open Targets associations for REXO2 are neurodegenerative disease, ulcerative colitis, lysosomal storage disease, blood protein measurement and Combined hyperlipidemia.
How long is the REXO2 protein?
The Homo sapiens REXO2 protein (UniProt Q9Y3B8) is 237 amino acids long.
Browse: Targets: R · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9Y3B8 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9Y3B8 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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