EKC/KEOPS complex subunit TPRKB (TPRKB)

About EKC/KEOPS complex subunit TPRKB

EKC/KEOPS complex subunit TPRKB (TPRKB) is a protein from Homo sapiens identified by UniProt accession Q9Y3C4, 175 residues long. MolForge cross-references it against 0 known binders and 18 disease associations.

Target properties

Protein name	EKC/KEOPS complex subunit TPRKB
UniProt accession	Q9Y3C4
Gene	TPRKB
Organism	Homo sapiens
Length	175 residues
Molecular weight	—
EC numbers	—
Target class	—
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (18)

Diseases linked to this target (Open Targets).

Galloway-Mowat syndrome · score 0.66
neurodegenerative disease · score 0.53
serum metabolite measurement · score 0.31
glomerular filtration rate · score 0.17
protein measurement · score 0.14
nephrotic syndrome · score 0.11
macrovascular complications of diabetes · score 0.06
smoking cessation · score 0.05
cancer · score 0.03
creatinine measurement · score 0.02

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9Y3C4-F1	alphafold	PREDICTED	95.48	—

Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9Y3C4.

Amino-acid sequence (175 residues)

MQLTHQLDLF PECRVTLLLF KDVKNAGDLR RKAMEGTIDG SLINPTVIVD PFQILVAANK AVHLYKLGKM KTRTLSTEII FNLSPNNNIS EALKKFGISA NDTSILIVYI EEGEKQINQE YLISQVEGHQ VSLKNLPEIM NITEVKKIYK LSSQEESIGT LLDAIICRMS TKDVL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards