Peptidyl-prolyl cis-trans isomerase-like 1 (PPIL1)
Homo sapiens — UniProt Q9Y3C6
Data last refreshed: (UniProt release unknown)
Key facts
Peptidyl-prolyl cis-trans isomerase-like 1 (PPIL1) is a protein from Homo sapiens identified by UniProt accession Q9Y3C6, 166 residues long. MolForge cross-references it against 0 known binders and 54 disease associations.
- UniProt accession: Q9Y3C6; gene symbol PPIL1.
- Organism: Homo sapiens.
- Length: 166 amino acids.
- Top disease associations (Open Targets): pontocerebellar hypoplasia, type 14, neurodegenerative disease and Non-syndromic pontocerebellar hypoplasia.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Peptidyl-prolyl cis-trans isomerase-like 1 |
|---|---|
| UniProt accession | Q9Y3C6 |
| Gene | PPIL1 |
| Organism | Homo sapiens |
| Length | 166 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (54)
Diseases linked to this target (Open Targets).
- pontocerebellar hypoplasia, type 14 · score 0.59
- neurodegenerative disease · score 0.53
- Non-syndromic pontocerebellar hypoplasia · score 0.40
- pontocerebellar hypoplasia · score 0.40
- Neurodevelopmental disorder · score 0.27
- genetic disorder · score 0.16
- unipolar depression · score 0.15
- heart rate variability measurement · score 0.13
- diet measurement · score 0.10
- pulse pressure measurement · score 0.09
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9Y3C6-F1 | alphafold | PREDICTED | 94.77 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9Y3C6.
Amino-acid sequence (166 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with PPIL1?
The strongest Open Targets associations for PPIL1 are pontocerebellar hypoplasia, type 14, neurodegenerative disease, Non-syndromic pontocerebellar hypoplasia, pontocerebellar hypoplasia and Neurodevelopmental disorder.
How long is the PPIL1 protein?
The Homo sapiens PPIL1 protein (UniProt Q9Y3C6) is 166 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9Y3C6 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9Y3C6 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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