Ubiquitin-fold modifier-conjugating enzyme 1 (UFC1)
Homo sapiens — UniProt Q9Y3C8
Data last refreshed: (UniProt release unknown)
Key facts
Ubiquitin-fold modifier-conjugating enzyme 1 (UFC1) is a protein from Homo sapiens identified by UniProt accession Q9Y3C8, 167 residues long. MolForge cross-references it against 0 known binders and 64 disease associations.
- UniProt accession: Q9Y3C8; gene symbol UFC1.
- Organism: Homo sapiens.
- Length: 167 amino acids.
- Top disease associations (Open Targets): neurodevelopmental disorder with spasticity and poor growth, Microcephaly and microcephaly.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Ubiquitin-fold modifier-conjugating enzyme 1 |
|---|---|
| UniProt accession | Q9Y3C8 |
| Gene | UFC1 |
| Organism | Homo sapiens |
| Length | 167 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (64)
Diseases linked to this target (Open Targets).
- neurodevelopmental disorder with spasticity and poor growth · score 0.66
- Microcephaly · score 0.37
- microcephaly · score 0.37
- neurodegenerative disease · score 0.37
- blood protein measurement · score 0.17
- mathematical ability · score 0.10
- non-small cell lung carcinoma · score 0.09
- Alzheimer disease · score 0.07
- family history of Alzheimer’s disease · score 0.07
- gonorrhea · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9Y3C8-F1 | alphafold | PREDICTED | 93.46 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9Y3C8.
Amino-acid sequence (167 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with UFC1?
The strongest Open Targets associations for UFC1 are neurodevelopmental disorder with spasticity and poor growth, Microcephaly, microcephaly, neurodegenerative disease and blood protein measurement.
How long is the UFC1 protein?
The Homo sapiens UFC1 protein (UniProt Q9Y3C8) is 167 amino acids long.
Browse: Targets: U · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9Y3C8 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9Y3C8 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.