Cytosolic iron-sulfur assembly component 2B (CIAO2B)
Homo sapiens — UniProt Q9Y3D0
Data last refreshed: (UniProt release unknown)
Key facts
Cytosolic iron-sulfur assembly component 2B (CIAO2B) is a protein from Homo sapiens identified by UniProt accession Q9Y3D0, 163 residues long. MolForge cross-references it against 0 known binders and 34 disease associations.
- UniProt accession: Q9Y3D0; gene symbol CIAO2B.
- Organism: Homo sapiens.
- Length: 163 amino acids.
- Top disease associations (Open Targets): idiopathic hypereosinophilic syndrome, hereditary neutrophilia and Felty's syndrome.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Cytosolic iron-sulfur assembly component 2B |
|---|---|
| UniProt accession | Q9Y3D0 |
| Gene | CIAO2B |
| Organism | Homo sapiens |
| Length | 163 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (34)
Diseases linked to this target (Open Targets).
- idiopathic hypereosinophilic syndrome · score 0.04
- hereditary neutrophilia · score 0.04
- Felty's syndrome · score 0.04
- bone quantitative ultrasound measurement · score 0.04
- dominant beta-thalassemia · score 0.03
- hemoglobin H disease · score 0.03
- hemoglobin C-beta-thalassemia syndrome · score 0.03
- erythroleukemia, familial, susceptibility to · score 0.03
- chronic myelogenous leukemia · score 0.03
- hemolytic anemia due to diphosphoglycerate mutase deficiency · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9Y3D0-F1 | alphafold | PREDICTED | 84.58 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9Y3D0.
Amino-acid sequence (163 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with CIAO2B?
The strongest Open Targets associations for CIAO2B are idiopathic hypereosinophilic syndrome, hereditary neutrophilia, Felty's syndrome, bone quantitative ultrasound measurement and dominant beta-thalassemia.
How long is the CIAO2B protein?
The Homo sapiens CIAO2B protein (UniProt Q9Y3D0) is 163 amino acids long.
Browse: Targets: C · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9Y3D0 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9Y3D0 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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