Mitochondrial fission 1 protein (FIS1)
Homo sapiens — UniProt Q9Y3D6
Data last refreshed: (UniProt release unknown)
Key facts
Mitochondrial fission 1 protein (FIS1) is a protein from Homo sapiens identified by UniProt accession Q9Y3D6, 152 residues long. MolForge cross-references it against 0 known binders and 185 disease associations.
- UniProt accession: Q9Y3D6; gene symbol FIS1.
- Organism: Homo sapiens.
- Length: 152 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, lymphocyte count and hemoglobin measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Mitochondrial fission 1 protein |
|---|---|
| UniProt accession | Q9Y3D6 |
| Gene | FIS1 |
| Organism | Homo sapiens |
| Length | 152 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (185)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.54
- lymphocyte count · score 0.31
- hemoglobin measurement · score 0.07
- Crigler-Najjar syndrome type 2 · score 0.06
- schizophrenia · score 0.06
- maple syrup urine disease · score 0.06
- sarcosinemia · score 0.06
- acute myeloid leukemia · score 0.06
- hepatocellular carcinoma · score 0.05
- appendicular lean mass · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9Y3D6-F1 | alphafold | PREDICTED | 77.93 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9Y3D6.
Amino-acid sequence (152 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with FIS1?
The strongest Open Targets associations for FIS1 are neurodegenerative disease, lymphocyte count, hemoglobin measurement, Crigler-Najjar syndrome type 2 and schizophrenia.
How long is the FIS1 protein?
The Homo sapiens FIS1 protein (UniProt Q9Y3D6) is 152 amino acids long.
Browse: Targets: F · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9Y3D6 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9Y3D6 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.